학술논문
Knowledge and Current Practices in Monogenic Uveitis: An International Survey by IUSG and AIDA Network
Document Type
article
Author
Carla Gaggiano; Vishali Gupta; Rupesh Agrawal; Marc D. De Smet; Bruno Frediani; Gian Marco Tosi; Maria Pia Paroli; Sudharshan Sridharan; Carlos E. Pavesio; Uwe Pleyer; Ekaterina V. Denisova; Kalpana Babu; Alejandra de-la-Torre; Peizeng Yang; Janet L. Davis; Emmett T. Cunningham; Ester Carreño; Debra Goldstein; Alex Fonollosa; Luca Cantarini; Lucia Sobrin; Claudia Fabiani
Source
Ophthalmology and Therapy, Vol 13, Iss 1, Pp 127-147 (2023)
Subject
Language
English
ISSN
2193-8245
2193-6528
2193-6528
Abstract
Abstract Introduction This study aims to explore awareness, knowledge, and diagnostic/therapeutic practices in monogenic uveitis (mU) among uveitis experts. Methods This is an explorative, cross-sectional survey study. An anonymous, semi-structured, electronic survey was delivered to uveitis experts from the Autoinflammatory Diseases Alliance (AIDA) Network and International Uveitis Study Group (IUSG). We included respondents answering ≥ 50% of the survey. Results Seventy-seven participants rated their knowledge of mU as proficient (3.9%), adequate (15.6%), sufficient (16.9%), or poor (63.6%). When asked about the first mU gene they thought of, 60.4% mentioned NOD2, 3.9% mentioned NLRP3 or MEFV, and 49.4% provided incorrect or no answers. Success rates in clinical scenarios varied from 15.6% to 55.8% and were higher for ophthalmologists working in multidisciplinary teams (p 0.05). The public healthcare system ensured a higher percentage of tests prescribed were obtained by patients compared to private insurances (p