학술논문
Sickle Cell Trait and Kidney Disease in People of African Ancestry With HIV
Document Type
article
Author
Rachel K.Y. Hung; Elizabeth Binns-Roemer; John W. Booth; Rachel Hilton; Julie Fox; Fiona Burns; Mark Harber; Andrew Ustianowski; Lisa Hamzah; James E. Burns; Amanda Clarke; David A. Price; Stephen Kegg; Denis Onyango; Beatriz Santana-Suarez; Lucy Campbell; Kate Bramham; Claire C. Sharpe; Caroline A. Sabin; Cheryl A. Winkler; Frank A. Post; John Booth; Anele Waters; James Hand; Chris Clarke; Sarah Murphy; Maurice Murphy; Marion Campbell; Celia Richardson; Alyson Knott; Gemma Weir; Rebecca Cleig; Helena Soviarova; Lisa Barbour; Tanya Adams; Vicky Kennard; Vittorio Trevitt; Rachael Jones; Jeremy Levy; Alexandra Schoolmeester; Serah Duro; May Rabuya; Deborah Jordan; Teresa Solano; Hiromi Uzu; Karen Williams; Julianne Lwanga; Linda Ekaette Reid-Amoruso; Hannah Gamlen; Robert J. Stocker; Fiona Ryan; Karina Mahiouz; Tess Cheetham; Claire Williams; Achyuta Nori; Caroline Thomas; Sivaraj Venkateshwaran; Jessica Doctor; Andrea Berlanga; Frank Post; Leigh McQueen; Priya Bhagwandin; Bee Barbini; Emily Wandolo; Tim Appleby; Lois Driver; Sophy Parr; Hongbo Deng; Julie Barber; Andrew Crowe; Chris Taylor; Mary Poulton; Vida Boateng; Marie-Pierre Klein; Caitlin O’Brien; Samuel Ohene-Adomako; Christian Buckingham; Daniel Trotman; Killian Quinn; Kate Flanagan; Verity Sullivan; Holly Middleditch; Itty Samuel; Elizabeth Hamlyn; Candice McDonald; Ana Canoso; Emeka Agbasi; Maria Liskova; Sarah Barber; Amanda Samarawickrama; Zoe Ottaway; Claire Norcross; Amelia Oliveira; Jane Minton; Gary Lamont; Ruby Cross; Gaushiya Saiyad; Shadia Ahmed; Rebecca Ashworth; Nicola Window; J. Murira; Khine Phyu; Gabriella Lindergard; Jonathan Shaw; Sarah Holland; Claire Fox; Jan Flaherty; Margaret-Anne Bevan; Valerie George; David Chadwick; Marie Branch; Pauline Lambert; Adele Craggs; Sarah Pett; Hinal Lukha; Nina Vora; Marzia Fiorino; Maria Muller Nunez; Deirdre Sally; Erica Pool; Rebecca Matthews; David Ashley Price; Tara Stothard; Bijal Patel; Ian McVittie; Ciara Kennedy; Uli Shwab; Brendan Payne; Sarah Duncan; Jill Dixon; Mathias Schmid; Adam Evans; Christopher Duncan; Ewan Hunter; Yusri Taha; Natasha Astill; Cheryl Winkler; Victor David; Jonathan Ainsworth; Rachel Vincent; Chloe Saad; Sarah Skinner; Hocine Azzoug; Judith Russell; Tarik Moussaoui; Emily Mabonga; Donna Ward; J. Francoise; W. Larbi; Sue Mitchell; A. Manning; V. Russell; Nnenna Ngwu; Jonathan Edwards; Nargis Hemat; Tom Fernandez; Filippo Ferro; Jorge Ferreira; Alice Nightingale; Tasha Oakes-Monger; Darwin Matila; Pedro Nogueira; Victoria Mutagwanya; Catherine Cosgrove; Catherine Emily Isitt; Helen Webb; Joyce Popoola; Kate Korley; Mark Mencias; Patricia Ribeiro; Rajeshwar Ramkhelawn; Sandra Oliva Lara; Sara Sajijad; Alan Winston; Amber Shaw; Claire Petersen; Kyle Ring; Melanie Rosenvinge; Thembi Moyo; Faith Odong; Katherine Gantert; Tina Ibe; Caroline Sabin; Teresa Hill
Source
Kidney International Reports, Vol 7, Iss 3, Pp 465-473 (2022)
Subject
Language
English
ISSN
2468-0249
Abstract
Introduction: Sickle cell trait (SCT) has been associated with chronic kidney disease (CKD) in African Americans, although evidence for its impact in Africans and people with HIV is currently lacking. We conducted a cross-sectional study investigating the association between SCT and kidney disease in people of African ancestry with HIV in the UK. Methods: The primary outcome was estimated glomerular filtration rate (eGFR) 50 mg/mmol), and albuminuria (albumin-to-creatinine ratio >3 mg/mmol). Multivariable logistic regression was used to estimate the associations between SCT and kidney disease outcomes. Results: A total of 2895 participants (mean age 48.1 [SD 10.3], 57.2% female) were included, of whom 335 (11.6%) had SCT and 352 (12.2%) had eGFR