학술논문
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Document Type
article
Author
Cristian Pattaro; Alexander Teumer; Mathias Gorski; Audrey Y. Chu; Man Li; Vladan Mijatovic; Maija Garnaas; Adrienne Tin; Rossella Sorice; Yong Li; Daniel Taliun; Matthias Olden; Meredith Foster; Qiong Yang; Ming-Huei Chen; Tune H. Pers; Andrew D. Johnson; Yi-An Ko; Christian Fuchsberger; Bamidele Tayo; Michael Nalls; Mary F. Feitosa; Aaron Isaacs; Abbas Dehghan; Pio d’Adamo; Adebowale Adeyemo; Aida Karina Dieffenbach; Alan B. Zonderman; Ilja M. Nolte; Peter J. van der Most; Alan F. Wright; Alan R. Shuldiner; Alanna C. Morrison; Albert Hofman; Albert V. Smith; Albert W. Dreisbach; Andre Franke; Andre G. Uitterlinden; Andres Metspalu; Anke Tonjes; Antonio Lupo; Antonietta Robino; Åsa Johansson; Ayse Demirkan; Barbara Kollerits; Barry I. Freedman; Belen Ponte; Ben A. Oostra; Bernhard Paulweber; Bernhard K. Krämer; Braxton D. Mitchell; Brendan M. Buckley; Carmen A. Peralta; Caroline Hayward; Catherine Helmer; Charles N. Rotimi; Christian M. Shaffer; Christian Müller; Cinzia Sala; Cornelia M. van Duijn; Aude Saint-Pierre; Daniel Ackermann; Daniel Shriner; Daniela Ruggiero; Daniela Toniolo; Yingchang Lu; Daniele Cusi; Darina Czamara; David Ellinghaus; David S. Siscovick; Douglas Ruderfer; Christian Gieger; Harald Grallert; Elena Rochtchina; Elizabeth J. Atkinson; Elizabeth G. Holliday; Eric Boerwinkle; Erika Salvi; Erwin P. Bottinger; Federico Murgia; Fernando Rivadeneira; Florian Ernst; Florian Kronenberg; Frank B. Hu; Gerjan J. Navis; Gary C. Curhan; George B. Ehret; Georg Homuth; Stefan Coassin; Gian-Andri Thun; Giorgio Pistis; Giovanni Gambaro; Giovanni Malerba; Grant W. Montgomery; Gudny Eiriksdottir; Gunnar Jacobs; Guo Li; H-Erich Wichmann; Harry Campbell; Helena Schmidt; Henri Wallaschofski; Henry Völzke; Hermann Brenner; Heyo K. Kroemer; Holly Kramer; Honghuang Lin; I. Mateo Leach; Ian Ford; Idris Guessous; Igor Rudan; Inga Prokopenko; Ingrid Borecki; Iris M. Heid; Ivana Kolcic; Ivana Persico; J. Wouter Jukema; James F. Wilson; Janine F. Felix; Jasmin Divers; Jean-Charles Lambert; Jeanette M. Stafford; Jean-Michel Gaspoz; Jennifer A. Smith; Jessica D. Faul; Jie Jin Wang; Jingzhong Ding; Joel N. Hirschhorn; John Attia; John B. Whitfield; John Chalmers; Jorma Viikari; Josef Coresh; Joshua C. Denny; Juha Karjalainen; Jyotika K. Fernandes; Karlhans Endlich; Katja Butterbach; Keith L. Keene; Kurt Lohman; Laura Portas; Lenore J. Launer; Leo-Pekka Lyytikäinen; Loic Yengo; Lude Franke; Luigi Ferrucci; Lynda M. Rose; Lyudmyla Kedenko; Madhumathi Rao; Maksim Struchalin; Marcus E. Kleber; Margherita Cavalieri; Margot Haun; Marilyn C. Cornelis; Marina Ciullo; Mario Pirastu; Mariza de Andrade; Mark A. McEvoy; Mark Woodward; Martin Adam; Massimiliano Cocca; Matthias Nauck; Medea Imboden; Melanie Waldenberger; Menno Pruijm; Marie Metzger; Michael Stumvoll; Michele K. Evans; Michele M. Sale; Mika Kähönen; Mladen Boban; Murielle Bochud; Myriam Rheinberger; Niek Verweij; Nabila Bouatia-Naji; Nicholas G. Martin; Nick Hastie; Nicole Probst-Hensch; Nicole Soranzo; Olivier Devuyst; Olli Raitakari; Omri Gottesman; Oscar H. Franco; Ozren Polasek; Paolo Gasparini; Patricia B. Munroe; Paul M. Ridker; Paul Mitchell; Paul Muntner; Christa Meisinger; Johannes H. Smit; ICBP Consortium; AGEN Consortium; CARDIOGRAM; CHARGe-Heart Failure Group; ECHOGen Consortium; Peter Kovacs; Philipp S. Wild; Philippe Froguel; Rainer Rettig; Reedik Mägi; Reiner Biffar; Reinhold Schmidt; Rita P. S. Middelberg; Robert J. Carroll; Brenda W. Penninx; Rodney J. Scott; Ronit Katz; Sanaz Sedaghat; Sarah H. Wild; Sharon L. R. Kardia; Sheila Ulivi; Shih-Jen Hwang; Stefan Enroth; Stefan Kloiber; Stella Trompet; Benedicte Stengel; Stephen J. Hancock; Stephen T. Turner; Sylvia E. Rosas; Sylvia Stracke; Tamara B. Harris; Tanja Zeller; Tatijana Zemunik; Terho Lehtimäki; Thomas Illig; Thor Aspelund; Tiit Nikopensius; Tonu Esko; Toshiko Tanaka; Ulf Gyllensten; Uwe Völker; Valur Emilsson; Veronique Vitart; Ville Aalto; Vilmundur Gudnason; Vincent Chouraki; Wei-Min Chen; Wilmar Igl; Winfried März; Wolfgang Koenig; Wolfgang Lieb; Ruth J. F. Loos; Yongmei Liu; Harold Snieder; Peter P. Pramstaller; Afshin Parsa; Jeffrey R. O’Connell; Katalin Susztak; Pavel Hamet; Johanne Tremblay; Ian H. de Boer; Carsten A. Böger; Wolfram Goessling; Daniel I. Chasman; Anna Köttgen; W. H. Linda Kao; Caroline S. Fox
Source
Nature Communications, Vol 7, Iss 1, Pp 1-19 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.