학술논문
Selectivity of Lewy body protein interactions along the aggregation pathway of α-synuclein
Document Type
article
Author
Source
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Subject
Language
English
ISSN
2399-3642
Abstract
To better understand the specific cascade of protein interactions that lead to the pathological aggregation of α-synuclein (wild-type and mutant forms), Leitão et al. present a method to measure interactions of monomeric, oligomeric, and fibrillar forms of α-syn with 65 proteins that were previously shown to be components of Lewy bodies. This approach is useful to understand the sequence of protein-binding events that lead to α-syn aggregation.