학술논문
HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis
Document Type
article
Author
Margaux Sevin; Lucia Kubovcakova; Nicolas Pernet; Sébastien Causse; Franck Vitte; Jean Luc Villeval; Catherine Lacout; Marine Cordonnier; Fernando Rodrigues-Lima; Gaétan Chanteloup; Matthieu Mosca; Marie-Lorraine Chrétien; Jean Noël Bastie; Sylvain Audia; Paul Sagot; Selim Ramla; Laurent Martin; Martin Gleave; Valérie Mezger; Radek Skoda; Isabelle Plo; Carmen Garrido; François Girodon; Aurélie de Thonel
Source
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Myelofibrosis is a chronic degenerative disorder characterized by progressive bone marrow fibrosis. Here, the authors show that the chaperone HSP27 contributes to myelofibrosis via regulation of the JAK2/STAT5 pathway, and that antisense oligonucleotides targeting HSP27 are effective in two mouse models of the disease