학술논문
Factor Xa cleaves SARS-CoV-2 spike protein to block viral entry and infection
Document Type
article
Author
Wenjuan Dong; Jing Wang; Lei Tian; Jianying Zhang; Erik W. Settles; Chao Qin; Daniel R. Steinken-Kollath; Ashley N. Itogawa; Kimberly R. Celona; Jinhee Yi; Mitchell Bryant; Heather Mead; Sierra A. Jaramillo; Hongjia Lu; Aimin Li; Ross E. Zumwalt; Sanjeet Dadwal; Pinghui Feng; Weiming Yuan; Sean P. J. Whelan; Paul S. Keim; Bridget Marie Barker; Michael A. Caligiuri; Jianhua Yu
Source
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
The serine protease factor Xa (FXa) is upregulated in COVID-19 patients and functions in the coagulation pathway. Here, Dong et al characterise the basis of its antiviral activity in the context of SARS-CoV-2 pandemic variants.