학술논문
Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years
Document Type
article
Author
Christine Durier; Laetitia Ninove; Maeva Lefebvre; Anne Radenne; Corinne Desaint; Jacques Ropers; Rebecca Bauer; Said Lebbah; Diane Carette; Marie Lachatre; Anne-Sophie Lecompte; Dominique Deplanque; Elisabeth Botelho-Nevers; Anne Conrad; Bertrand Dussol; Zoha Maakaroun-Vermesse; Giovanna Melica; Jean-François Nicolas; Renaud Verdon; Jacques Kiladjian; Paul Loubet; Catherine Schmidt-Mutter; Christian Dualé; Séverine Ansart; Stéphane Priet; Axel Levier; Diana Molino; Louis-Victorien Vieillard; Béatrice Parfait; Jean-Daniel Lelièvre; Eric Tartour; Xavier de Lamballerie; Odile Launay; ANRS0002S CoviCompareP Group; AP-HP CoviCompareM Group; Biological resource centers; Laboratories; Trial coordination; Sponsor; Scientific Committee
Source
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Immune response induced by COVID-19 vaccine booster against delta and omicron variants was assessed in 65 adults (65–84 years old) early aftesr a first booster dose. An increase in SARS-CoV-2 neutralizing antibodies was shown in individuals not previously infected without evidence of an age-related effect, with lower increase in those infected before a single dose of primary vaccination. Of note, humoral response was observed only starting from the 5th day after the boost.