학술논문
Topoisomerase 2β Induces DNA Breaks To Regulate Human Papillomavirus Replication
Document Type
article
Source
mBio, Vol 12, Iss 1 (2021)
Subject
Language
English
ISSN
2161-2129
2150-7511
81768338
2150-7511
81768338
Abstract
High-risk human papillomaviruses (HPVs) infect epithelial cells and induce viral genome amplification upon differentiation. HPV proteins activate DNA damage repair pathways by inducing high numbers of DNA breaks in both viral and cellular DNAs.