학술논문
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus
Document Type
article
Author
Takanori Furukawa; Norman van Rhijn; Marcin Fraczek; Fabio Gsaller; Emma Davies; Paul Carr; Sara Gago; Rachael Fortune-Grant; Sayema Rahman; Jane Mabey Gilsenan; Emma Houlder; Caitlin H. Kowalski; Shriya Raj; Sanjoy Paul; Peter Cook; Josie E. Parker; Steve Kelly; Robert A. Cramer; Jean-Paul Latgé; Scott Moye-Rowley; Elaine Bignell; Paul Bowyer; Michael J. Bromley
Source
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Resistance to primary treatments of invasive aspergillosis is growing. Here, the authors generate a knockout library for 484 transcription factors in Aspergillus fumigatus, and show that loss of the NCT complex leads to cross-resistance to all primary and some salvage therapeutics without affecting pathogenicity.