학술논문
The oldest unvaccinated Covid-19 survivors in South America
Document Type
article
Author
Mateus V. de Castro; Monize V. R. Silva; Michel S. Naslavsky; Marilia O. Scliar; Kelly Nunes; Maria Rita Passos-Bueno; Erick C. Castelli; Jhosiene Y. Magawa; Flávia L. Adami; Ana I. S. Moretti; Vivian L. de Oliveira; Silvia B. Boscardin; Edecio Cunha-Neto; Jorge Kalil; Emmanuelle Jouanguy; Paul Bastard; Jean-Laurent Casanova; Mauricio Quiñones-Vega; Patricia Sosa-Acosta; Jéssica S. de Guedes; Natália P. de Almeida; Fábio C. S. Nogueira; Gilberto B. Domont; Keity S. Santos; Mayana Zatz
Source
Immunity & Ageing, Vol 19, Iss 1, Pp 1-9 (2022)
Subject
Language
English
ISSN
1742-4933
Abstract
Abstract Background Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied three Brazilian supercentenarians, older than 110 years, who survived Covid-19 in 2020 before being vaccinated. Results Despite their advanced age, humoral immune response analysis showed that these individuals displayed robust levels of IgG and neutralizing antibodies (NAbs) against SARS-CoV-2. Enrichment of plasma proteins and metabolites related to innate immune response and host defense was also observed. None presented autoantibodies (auto-Abs) to type I interferon (IFN). Furthermore, these supercentenarians do not carry rare variants in genes underlying the known inborn errors of immunity, including particular inborn errors of type I IFN. Conclusion These observations suggest that their Covid-19 resilience might be a combination of their genetic background and their innate and adaptive immunity.