학술논문
Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity
Document Type
article
Author
Nikaïa Smith; Céline Possémé; Vincent Bondet; Jamie Sugrue; Liam Townsend; Bruno Charbit; Vincent Rouilly; Violaine Saint-André; Tom Dott; Andre Rodriguez Pozo; Nader Yatim; Olivier Schwartz; Minerva Cervantes-Gonzalez; Jade Ghosn; Paul Bastard; Jean Laurent Casanova; Tali-Anne Szwebel; Benjamin Terrier; Niall Conlon; Cliona O’Farrelly; Clíona Ní Cheallaigh; Nollaig M. Bourke; Darragh Duffy
Source
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
The interferon response has been shown to be linked to severity of SARS-CoV-2 infection and is an essential component of the immune response to COVID-19. Here the authors stratify patients according to COVID-19 severity and asses the interferon response showing defective responses in severe infection and highlight the importance of assay variables and confounding factors that impact the detection of interferon.