학술논문
Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling
Document Type
article
Author
Source
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Excess caloric intake leads to increased thermogenesis in brown adipose tissue, to limit weight gain. Here, the authors show that neuropeptide FF receptor-2 signalling promotes thermogenesis via control of NPY expression in the arcuate nucleus, and that it absence in mice leads to a failure of activation of diet-induced thermogenesis and the development of exacerbated obesity.