학술논문
Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing
Document Type
article
Author
Baolei Yuan; Xuan Zhou; Keiichiro Suzuki; Gerardo Ramos-Mandujano; Mengge Wang; Muhammad Tehseen; Lorena V. Cortés-Medina; James J. Moresco; Sarah Dunn; Reyna Hernandez-Benitez; Tomoaki Hishida; Na Young Kim; Manal M. Andijani; Chongwei Bi; Manching Ku; Yuta Takahashi; Jinna Xu; Jinsong Qiu; Ling Huang; Christopher Benner; Emi Aizawa; Jing Qu; Guang-Hui Liu; Zhongwei Li; Fei Yi; Yanal Ghosheh; Changwei Shao; Maxim Shokhirev; Patrizia Comoli; Francesco Frassoni; John R. Yates; Xiang-Dong Fu; Concepcion Rodriguez Esteban; Samir Hamdan; Mo Li; Juan Carlos Izpisua Belmonte
Source
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Wiskott-Aldrich syndrome is caused by mutations in WASP, but the underlying mechanisms remain to be explored. Here the authors reveal that WASP deficiency results in aberrant RNA splicing, and that WASP regulates the transcription of splicing factor genes and co-transcriptional RNA splicing via a phase-separation process that involves splicing factors and nascent RNA.