학술논문
Immediate Hypersensitivity to Contrast Agents: The French 5-year CIRTACI Study
Document Type
article
Author
Olivier Clement; Pascale Dewachter; Claudie Mouton-Faivre; Camille Nevoret; Laurence Guilloux; Evelyne Bloch Morot; Sandrine Katsahian; Dominique Laroche; Martine Audebert; Béatrice Benabes-Jezraoui; Yves Benoit; Sylvie Beot; Frédéric Berard; Yves Berthezene; Philippe Bertrand; Juliette Bouffard; Jean-Luc Bourrain; Bruno Boyer; Marie-France Carette; Christine Caron-Poitreau; Béatrice Cavestri; Jean Pierre Cercueil; Denis-André Charpin; Evelyne Collet; Arielle Crombe-Ternamian; Jacques Dalmas; Eric Decoux; Marie-France Defrance; Yvonne Delaval; Pascal Demoly; Claude Depriester; Pascale Depriester; Alain Didier; Martine Drouet; Benoît Dupas; Dominique Dupre-Goetchebeur; Charles Dzviga; Christine Fabre; Gilbert Ferretti; Corinne Fourre-Jullian; Pascal Girardin; Jacques Giron; Marion Gouitaa; Nicolas Grenier; Lydie Guenard Bilbault; Stéphane Guez; Nathalie Gunera-Saad; Jean-François Heautot; Dominique Herbin; Cyrille Hoarau; Claude Jacquot; Christian Julien; Laurent Laborie; Claude Lambert; Pascal Larroche; Xavier Leclerc; Laurent Lemaitre; Francisque Leynadier; Agnès Lillo-Le-Louet; Jean-Pierre Louvel; Nathalie Louvier; Marie-Madeleine Lucas; Geneviève Meites; Nicolas Mennesson; Liliane Metge; Yannick Meunier; Laurence Monnier-Cholley; Mariano Musacchio; Brigitte Nicolie; Gisèle Occelli; Hélène Oesterle; Francine Paisant-Thouveny; Michel Panuel; Nadine Railhac; Frédérique Rety-Jacob; Cécile Rochefort-Morel; Catherine Roy; Philippe Sarlieve; Musa Sesay; Catherine Sgro; Patrice Taourel; Patrick Terrier; Odile Theissen; Ingrid Topenot; Jocelyne Valfrey; Francis Veillon; Marie-Claude Vergnaud; Charles Veyret; Denis Vincent; Benoit Wallaert; François Wessel; Marc Zins
Source
EClinicalMedicine, Vol 1, Iss , Pp 51-61 (2018)
Subject
Language
English
ISSN
2589-5370
Abstract
Background: Iodinated and gadolinium-based contrast media (ICM; GBCM) induce immediate hypersensitivity (IH) reactions. Differentiating allergic from non-allergic IH is crucial; allergy contraindicates the culprit agent for life. We studied frequency of allergic IH among ICM or GBCM reactors. Methods: Patients were recruited in 31 hospitals between 2005 and 2009. Clinical symptoms, plasma histamine and tryptase concentrations and skin tests were recorded. Allergic IH was diagnosed by intradermal tests (IDT) with the culprit CM diluted 1:10, “potentially allergic” IH by positive IDT with pure CM, and non-allergic IH by negative IDT. Findings: Among 245 skin-tested patients (ICM = 209; GBCM = 36), allergic IH to ICM was identified in 41 (19.6%) and to GBCM in 10 (27.8%). Skin cross-reactivity was observed in 11 patients with ICM (26.8%) and 5 with GBCM (50%). Allergy frequency increased with clinical severity and histamine and tryptase concentrations (p 50% of life-threatening ones. GBCM and ICM triggered comparable IH reactions in frequency and severity. Cross-reactivity was frequent, especially for GBCM. We propose considering skin testing with pure contrast agent, as it is more sensitive than the usual 1:10 dilution criteria.