학술논문
Clinical and transcriptomic features of persistent exacerbation‐prone severe asthma in U‐BIOPRED cohort
Document Type
article
Author
Uruj Hoda; Stelios Pavlidis; Aruna T. Bansal; Kentaro Takahashi; Sile Hu; Francois Ng Kee Kwong; Christos Rossios; Kai Sun; Pankaj Bhavsar; Matthew Loza; Frederic Baribaud; Pascal Chanez; Stephen J. Fowler; Ildiko Horvath; Paolo Montuschi; Florian Singer; Jacek Musial; Barbro Dahlen; Norbert Krug; Thomas Sandstrom; Dominic E. Shaw; Rene Lutter; Louise J. Fleming; Peter H. Howarth; Massimo Caruso; Ana R. Sousa; Julie Corfield; Charles Auffray; Bertrand De Meulder; Diane Lefaudeux; Sven‐Erik Dahlen; Ratko Djukanovic; Peter J. Sterk; Yike Guo; Ian M. Adcock; Kian Fan Chung; the U‐BIOPRED study group
Source
Clinical and Translational Medicine, Vol 12, Iss 4, Pp n/a-n/a (2022)
Subject
Language
English
ISSN
2001-1326
Abstract
Abstract Background Exacerbation‐prone asthma is a feature of severe disease. However, the basis for its persistency remains unclear. Objectives To determine the clinical and transcriptomic features of frequent exacerbators (FEs) and persistent FEs (PFEs) in the U‐BIOPRED cohort. Methods We compared features of FE (≥2 exacerbations in past year) to infrequent exacerbators (IE,