학술논문
Combining genomics and epidemiology to track mumps virus transmission in the United States.
Document Type
article
Author
Shirlee Wohl; Hayden C Metsky; Stephen F Schaffner; Anne Piantadosi; Meagan Burns; Joseph A Lewnard; Bridget Chak; Lydia A Krasilnikova; Katherine J Siddle; Christian B Matranga; Bettina Bankamp; Scott Hennigan; Brandon Sabina; Elizabeth H Byrne; Rebecca J McNall; Rickey R Shah; James Qu; Daniel J Park; Soheyla Gharib; Susan Fitzgerald; Paul Barreira; Stephen Fleming; Susan Lett; Paul A Rota; Lawrence C Madoff; Nathan L Yozwiak; Bronwyn L MacInnis; Sandra Smole; Yonatan H Grad; Pardis C Sabeti
Source
PLoS Biology, Vol 18, Iss 2, p e3000611 (2020)
Subject
Language
English
ISSN
1544-9173
1545-7885
1545-7885
Abstract
Unusually large outbreaks of mumps across the United States in 2016 and 2017 raised questions about the extent of mumps circulation and the relationship between these and prior outbreaks. We paired epidemiological data from public health investigations with analysis of mumps virus whole genome sequences from 201 infected individuals, focusing on Massachusetts university communities. Our analysis suggests continuous, undetected circulation of mumps locally and nationally, including multiple independent introductions into Massachusetts and into individual communities. Despite the presence of these multiple mumps virus lineages, the genomic data show that one lineage has dominated in the US since at least 2006. Widespread transmission was surprising given high vaccination rates, but we found no genetic evidence that variants arising during this outbreak contributed to vaccine escape. Viral genomic data allowed us to reconstruct mumps transmission links not evident from epidemiological data or standard single-gene surveillance efforts and also revealed connections between apparently unrelated mumps outbreaks.