학술논문
Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture
Document Type
article
Author
Simon Stritt; Paquita Nurden; Remi Favier; Marie Favier; Silvia Ferioli; Sanjeev K. Gotru; Judith M M. van Eeuwijk; Harald Schulze; Alan T. Nurden; Michele P. Lambert; Ernest Turro; Stephanie Burger-Stritt; Masayuki Matsushita; Lorenz Mittermeier; Paola Ballerini; Susanna Zierler; Michael A. Laffan; Vladimir Chubanov; Thomas Gudermann; Bernhard Nieswandt; Attila Braun
Source
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
Although Mg2+is vital for platelet activation and aggregation, its regulation in these cells is still largely unknown. Here, the authors show that TRPM7, a cation channel and a protein kinase, regulates thrombopoiesis and platelet size by affecting the cytoskeleton of these cells in mice and humans.