학술논문
Gene expression responses to anti-tuberculous drugs in a whole blood model
Document Type
article
Author
Source
BMC Microbiology, Vol 20, Iss 1, Pp 1-9 (2020)
Subject
Language
English
ISSN
1471-2180
Abstract
Abstract Background There is a need for better tools to evaluate new or repurposed TB drugs. The whole blood bactericidal activity (WBA) assay has been advocated for this purpose. We investigated whether transcriptional responses in the WBA assay resemble TB responses in vivo, and whether the approach might additionally reveal mechanisms of action. Results 1422 of 1798 (79%) of differentially expressed genes in WBA incubated with the standard combination of rifampicin, isoniazid, pyrazinamide and ethambutol were also expressed in sputum (P