학술논문
Associations between female birth sex and risk of chronic kidney disease development among people with HIV in the USA: A longitudinal, multicentre, cohort study
Document Type
article
Author
Brittany A. Shelton; Deirdre Sawinski; Paul A. MacLennan; Wonjun Lee; Christina Wyatt; Girish Nadkarni; Huma Fatima; Shikha Mehta; Heidi M. Crane; Paige Porrett; Bruce Julian; Richard D. Moore; Katerina Christopoulos; Jeffrey M. Jacobson; Elmi Muller; Joseph J. Eron; Michael Saag; Inga Peter; Jayme E. Locke
Source
EClinicalMedicine, Vol 53, Iss , Pp 101653- (2022)
Subject
Language
English
ISSN
2589-5370
Abstract
Summary: Background: Women represent a meaningful proportion of new HIV diagnoses, with Black women comprising 58% of new diagnoses among women. As HIV infection also increases risk of chronic kidney disease (CKD), understanding CKD risk among women with HIV (WWH), particularly Black women, is critical. Methods: In this longitudinal cohort study of people with HIV (PWH) enrolled in CFAR Network of Integrated Clinical Systems (CNICS), a multicentre study comprised of eight academic medical centres across the United States from Jan 01, 1996 and Nov 01, 2019, adult PWH were excluded if they had ≤2 serum creatinine measurements, developed CKD prior to enrollment, or identified as intersex or transgendered, leaving a final cohort of 33,998 PWH. The outcome was CKD development, defined as estimated glomerular filtration rate (eGFR)