학술논문
Cytomegalovirus infections in infants in Uganda: Newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus
Document Type
article
Author
Christine Hehnly; Paddy Ssentongo; Lisa M. Bebell; Kathy Burgoine; Joel Bazira; Claudio Fronterre; Elias Kumbakumba; Ronald Mulondo; Edith Mbabazi-Kabachelor; Sarah U. Morton; Joseph Ngonzi; Moses Ochora; Peter Olupot-Olupot; John Mugamba; Justin Onen; Drucilla J. Roberts; Kathryn Sheldon; Shamim A. Sinnar; Jasmine Smith; Peter Ssenyonga; Julius Kiwanuka; Joseph N. Paulson; Frederick A. Meier; Jessica E. Ericson; James R. Broach; Steven J. Schiff
Source
International Journal of Infectious Diseases, Vol 118, Iss , Pp 24-33 (2022)
Subject
Language
English
ISSN
1201-9712
Abstract
Objectives: To estimate the prevalence of cytomegalovirus (CMV) infections among newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus in Uganda. Design and Methods: Three populations—newborn-mother pairs, neonates with sepsis, and infants (≤3 months) with nonpostinfectious (NPIH) or postinfectious (PIH) hydrocephalus—were evaluated for CMV infection at 3 medical centers in Uganda. Quantitative PCR (qPCR) was used to characterize the prevalence of CMV. Results: The overall CMV prevalence in 2498 samples across all groups was 9%. In newborn-mother pairs, there was a 3% prevalence of cord blood CMV positivity and 33% prevalence of maternal vaginal shedding. In neonates with clinical sepsis, there was a 2% CMV prevalence. Maternal HIV seropositivity (adjusted odds ratio [aOR] 25.20; 95% confidence interval [CI] 4.43–134.26; p = 0.0001), residence in eastern Uganda (aOR 11.06; 95% CI 2.30–76.18; p = 0.003), maternal age