학술논문
Integrated Analysis Reveals That miR-193b, miR-671, and TREM-1 Correlate With a Good Response to Treatment of Human Localized Cutaneous Leishmaniasis Caused by Leishmania braziliensis
Document Type
article
Author
Sara Nunes; Icaro Bonyek Silva; Mariana Rosa Ampuero; Almério Libório Lopes de Noronha; Lígia Correia Lima de Souza; Thaizza Cavalcante Correia; Ricardo Khouri; Viviane Sampaio Boaventura; Aldina Barral; Pablo Ivan Pereira Ramos; Cláudia Brodskyn; Pablo Rafael Silveira Oliveira; Natalia Machado Tavares
Source
Frontiers in Immunology, Vol 9 (2018)
Subject
Language
English
ISSN
1664-3224
Abstract
Localized cutaneous leishmaniasis (LCL) is a chronic disease characterized by ulcerated skin lesion(s) and uncontrolled inflammation. The mechanisms underlying the pathogenesis of LCL are not completely understood, and little is known about posttranscriptional regulation during LCL. MicroRNAs (miRNAs) are non-coding small RNAs that regulate gene expression and can be implicated in the pathogenesis of LCL. We investigated the involvement of miRNAs and their targets genes in human LCL using publicly available transcriptome data sets followed by ex vivo validation. Initial analysis highlighted that miRNA expression is altered during LCL, as patients clustered separately from controls. Joint analysis identified eight high confidence miRNAs that had altered expression (−1.5 ≤ fold change ≥ 1.5; p