학술논문
Role of Early Assesment of Diuresis and Natriuresis in Detecting In-Hospital Diuretic Resistance in Acute Heart Failure
Document Type
article
Author
Belén García-Magallón; Marta Cobo-Marcos; Aitor Dávila Martiarena; Esther Montero Hernández; Maria Luisa Martín Jiménez; Aránzazu Martín García; Daniel De Castro Campos; Paula Vela Martín; Fernando Hernández Terciado; Ramón Garrido González; Andrea Matutano Muñoz; Daniel Escribano García; Fernando Domínguez; Ana Sainz Herrero; Camino Gómez Peñalba; Pablo Garcia-Pavia; Javier Segovia
Source
Frontiers in Physiology, Vol 13 (2022)
Subject
Language
English
ISSN
1664-042X
Abstract
Background and Purpose: European Guidelines recommend early evaluation of diuresis and natriuresis after the first administration of diuretic to identify patients with insufficient diuretic response during acute heart failure. The aim of this work is to evaluate the prevalence and characteristics of patients with insufficient diuretic response according to this new algorithm.Methods: Prospective observational single centre study of consecutive patients with acute heart failure and congestive signs. Clinical evaluation, echocardiography and blood tests were performed. Diuretic naïve patients received 40 mg of intravenous furosemide. Patients on an oupatient diuretic regimen received 2 times the ambulatory dose. The diuresis volume was assessed 6 h after the first loop diuretic administration, and a spot urinary sample was taken after 2 h. Insufficient diuretic response was defined as natriuresis