학술논문
Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapy
Document Type
article
Author
Luz M. Medrano; Mónica Gutiérrez-Rivas; Julià Blanco; Marcial García; María A. Jiménez-Sousa; Yolanda M. Pacheco; Marta Montero; José Antonio Iribarren; Enrique Bernal; Onofre Juan Martínez; José M. Benito; Norma Rallón; Salvador Resino; CoRIS and the HIV Biobank integrated in the Spanish AIDS Research Network Project RIS/EPICLIN 10_
Source
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-8 (2018)
Subject
Language
English
ISSN
1479-5876
Abstract
Abstract Background The mitochondrial DNA (mtDNA) seems to influence in a large number of diseases, including HIV infection. Moreover, there is a substantial inter-individual variability in the CD4+ recovery in HIV-infected patients on combination antiretroviral therapy (cART). Our study aimed to analyze the association between mtDNA haplogroups and CD4+ recovery in HIV-infected patients on cART. Methods This is a retrospective study of 324 naïve cART patients with CD4+ 9.65 CD4+ cells/mm3/month) than patients without haplogroup H (p = 0.032). The adjusted logistic regression showed that patients carrying haplogroup H had a higher likelihood of achieving a CD4+ recovery > 9.65 CD4+ cells/mm3/month [adjusted odds ratio (aOR) = 1.75 (95% CI = 1.04; 2.95); p = 0.035]. Conclusions European mitochondrial haplogroup H was associated with the improved CD4+ recovery in HIV-infected patients starting cART with CD4+