학술논문
Characteristics of patients with COVID-19 who have deteriorating chest X-ray findings within 48 h: a retrospective cohort study
Document Type
article
Author
Tatsuya Kusumoto; Shotaro Chubachi; Ho Namkoong; Hiromu Tanaka; Ho Lee; Shiro Otake; Kensuke Nakagawara; Takahiro Fukushima; Atsuho Morita; Mayuko Watase; Takanori Asakura; Katsunori Masaki; Hirofumi Kamata; Makoto Ishii; Naoki Hasegawa; Norihiro Harada; Tetsuya Ueda; Soichiro Ueda; Takashi Ishiguro; Ken Arimura; Fukuki Saito; Takashi Yoshiyama; Yasushi Nakano; Yoshikazu Mutoh; Yusuke Suzuki; Ryuya Edahiro; Koji Murakami; Yasunori Sato; Yukinori Okada; Ryuji Koike; Yuko Kitagawa; Katsushi Tokunaga; Akinori Kimura; Seiya Imoto; Satoru Miyano; Seishi Ogawa; Takanori Kanai; Koichi Fukunaga
Source
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract The severity of chest X-ray (CXR) findings is a prognostic factor in patients with coronavirus disease 2019 (COVID-19). We investigated the clinical and genetic characteristics and prognosis of patients with worsening CXR findings during early hospitalization. We retrospectively included 1656 consecutive Japanese patients with COVID-19 recruited through the Japan COVID-19 Task Force. Rapid deterioration of CXR findings was defined as increased pulmonary infiltrates in ≥ 50% of the lung fields within 48 h of admission. Rapid deterioration of CXR findings was an independent risk factor for death, most severe illness, tracheal intubation, and intensive care unit admission. The presence of consolidation on CXR, comorbid cardiovascular and chronic obstructive pulmonary diseases, high body temperature, and increased serum aspartate aminotransferase, potassium, and C-reactive protein levels were independent risk factors for rapid deterioration of CXR findings. Risk variant at the ABO locus (rs529565-C) was associated with rapid deterioration of CXR findings in all patients. This study revealed the clinical features, genetic features, and risk factors associated with rapid deterioration of CXR findings, a poor prognostic factor in patients with COVID-19.