학술논문
Impact of accumulative smoking exposure and chronic obstructive pulmonary disease on COVID-19 outcomes: report based on findings from the Japan COVID-19 task force
Document Type
article
Author
Mayuko Watase; Katsunori Masaki; Shotaro Chubachi; Ho Namkoong; Hiromu Tanaka; Ho Lee; Takahiro Fukushima; Shiro Otake; Kensuke Nakagawara; Tatsuya Kusumoto; Takanori Asakura; Hirofumi Kamata; Makoto Ishii; Naoki Hasegawa; Yoshitaka Oyamada; Norihiro Harada; Tetsuya Ueda; Soichiro Ueda; Takashi Ishiguro; Ken Arimura; Fukuki Saito; Takashi Yoshiyama; Yasushi Nakano; Yoshikazu Mutoh; Yusuke Suzuki; Ryuya Edahiro; Hirohito Sano; Yasunori Sato; Yukinori Okada; Ryuji Koike; Yuko Kitagawa; Katsushi Tokunaga; Akinori Kimura; Seiya Imoto; Satoru Miyano; Seishi Ogawa; Takanori Kanai; Koichi Fukunaga
Source
International Journal of Infectious Diseases, Vol 128, Iss , Pp 121-127 (2023)
Subject
Language
English
ISSN
1201-9712
Abstract
Objectives: Smoking and chronic obstructive pulmonary disease (COPD) are risk factors for severe COVID-19. However, limited literature exists on the effect of COPD and smoking on COVID-19 outcomes. This study examined the impact of smoking exposure in pack-years (PY) and COPD on COVID-19 outcomes among smokers in Japan. Methods: The study included 1266 smokers enrolled by the Japan COVID-19 task force between February 2020 and December 2021. PY and COPD status was self-reported by patients. Patients were classified into the non-COPD (n = 1151) and COPD (n = 115) groups; the non-COPD group was further classified into 30 PY (n = 361). The study outcome was the need for invasive mechanical ventilation (IMV). Results: The incidence of IMV increased with increasing PY and was highest in the COPD group (30 PY = 15.2%, COPD = 26.1%; P 30 PY and COPD groups through univariate (odds ratio [OR]: >30 PY = 2.11, COPD = 4.14) and multivariate (OR: >30 PY = 2.38; COPD = 7.94) analyses. Increasing PY number was also associated with increased IMV requirement in patients aged