학술논문
Targeting QKI-7 in vivo restores endothelial cell function in diabetes
Document Type
article
Author
Source
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Vascular endothelial cell (EC) dysfunction contributes to the occurrence of diabetic complications. Here the authors report that in diabetic conditions, upregulation of the RNA binding protein QKI-7 in ECs due to the imbalance of RNA splicing factors CUG-BP and hnRNPM contributes to EC dysfunction, and that in vivo QKI-7 silencing improves blood flow recovery in diabetic mice with limb ischemia.