학술논문
Atropine for critical care intubation in a cohort of 264 children and reduced mortality unrelated to effects on bradycardia.
Document Type
article
Author
Source
PLoS ONE, Vol 8, Iss 2, p e57478 (2013)
Subject
Language
English
ISSN
1932-6203
Abstract
BACKGROUND: Atropine has is currently recommended to facilitate haemodynamic stability during critical care intubation. Our objective was to determine whether atropine use at induction influences ICU mortality. METHODOLOGY/PRINCIPAL FINDINGS: A 2-year prospective, observational study of all first non-planned intubations, September 2007-9 in PICU and Intensive Care Transport team of Hôpital Robert Debré, Paris, 4 other PICUs and 5 NICUs in the Paris Region, France. Follow-up was from intubation to ICU discharge. A propensity score was used to adjust for patient specific characteristics influencing atropine prescription. 264/333 (79%) intubations were included. The unadjusted ICU mortality was 7.2% (9/124) for those who received atropine compared to 15.7% (22/140) for those who did not (OR 0.42, 95%CI 0.19-0.95, p=0.04). One child died during intubation (1/264, 0.4%). Two age sub-groups of neonates (≤28 days) and older children (>28 days,