학술논문
ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling
Document Type
article
Author
Source
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
STING is an intracellular sensor of pathogen- or host-derived DNA. In this study, the authors identify an ESCRT complex that regulates STING degradation, thus acting as a homeostatic regulator of STING signalling and type-I interferon responses.