학술논문
Multimodal Imaging-Based Phenotyping of a Singaporean Hospital-Based Cohort of High Myopia Patients
Document Type
article
Author
Kai Yuan Tey; Quan V. Hoang; Isabella Q. Loh; Yee Shan Dan; Qiu Ying Wong; Daryle Jason G. Yu; Vivi R. Yandri; Marcus Ang; Gemmy C. M. Cheung; Shu Yen Lee; Tien Yin Wong; SNEC Retina Group; Rachel S. Chong; Chee Wai Wong; Anna Cheng; Sim Tan; Beau James Fenner; Choi Mun Chan; Ian Yew San Yeo; Kelvin Yi Chong Teo; Ranjana Mathur; Shaun Sebastian Sim; Wiryasaputra Shaan; Andrew Shih Hsiang Tsai; Chong Lye Ang; Ning Cheung; Ting Shu Wei Daniel; Doric Wen Kuan Wong; Edmund Yick Mun Wong; Gavin Siew Wei Tan; Hyungtaek Rim
Source
Frontiers in Medicine, Vol 8 (2022)
Subject
Language
English
ISSN
2296-858X
Abstract
Purpose: To assess the effect of axial length (AL) on the prevalence of pathologic myopia (PM) and associated myopic features in a Singaporean hospital-based cohort of patient with high myopia (HM).Methods: In total, 923 HM eyes from 495 individuals were recruited from the Myopic and Pathologic Eyes in Singapore (MyoPES) cohort and underwent ocular biometry, fundus photography, fundus autofluorescence, and swept-source optical coherence tomography (SS-OCT). Images were analyzed for the presence of myopic macular degeneration (MMD), myopic choroidal neovascularization (mCNV), myopic traction maculopathy (MTM), peripapillary atrophy (PPA), myopic tilted disc, posterior staphyloma (PS), dome-shaped macula (DSM), vitremacular adhesions (VMA), and the epiretinal membrane (ERM). Eyes were stratified into quartiles based on ALs to determine cut-off values to perform comparisons between shorter-length and longer-length groups. A χ2-test was done to determine the difference in the prevalence of pathologies between groups.Results: Overall, mean AL was 29.2 ± 2.2 mm (range 25.0–36.7 mm). Myopic macular degeneration, PPA, myopic tilted disc, and ERM have AL threshold of ≥27.5 mm, whereas MTM has an AL threshold of ≥29.0 mm. We found that there was a significantly higher prevalence of MMD (88.2 vs. 49.4%; p < 0.001), PPA (98.1 vs. 80.1%; p < 0.001), myopic tilted disc (72.7 vs. 50.2%; p < 0.001), and ERM (81.4 vs. 17.3%; p = 0.003) in eyes with AL ≥ 27.5 mm vs. eyes without AL