학술논문
Cellular mechanisms linking cancers to obesity
Document Type
article
Author
Source
Cell Stress, Vol 5, Iss 5, Pp 55-72 (2021)
Subject
Language
English
ISSN
2523-0204
Abstract
Obesity is epidemiologically linked to 13 forms of cancer. The local and systemic obese environment is complex and likely affect tumors through multiple avenues. This includes modulation of cancer cell phenotypes and the composition of the tumor microenvironment. A molecular understanding of how obesity links to cancer holds promise for identifying candidate genes for targeted therapy for obese cancer patient. Herein, we review both the cell-autonomous and non-cell-autonomous mechanisms linking obesity and cancer as well as provide an overview of the mouse model systems applied to study this.