학술논문
Contribution of allelic imbalance to colorectal cancer
Document Type
article
Author
Kimmo Palin; Esa Pitkänen; Mikko Turunen; Biswajyoti Sahu; Päivi Pihlajamaa; Teemu Kivioja; Eevi Kaasinen; Niko Välimäki; Ulrika A. Hänninen; Tatiana Cajuso; Mervi Aavikko; Sari Tuupanen; Outi Kilpivaara; Linda van den Berg; Johanna Kondelin; Tomas Tanskanen; Riku Katainen; Marta Grau; Heli Rauanheimo; Roosa-Maria Plaketti; Aurora Taira; Päivi Sulo; Tuomo Hartonen; Kashyap Dave; Bernhard Schmierer; Sandeep Botla; Maria Sokolova; Anna Vähärautio; Kornelia Gladysz; Halit Ongen; Emmanouil Dermitzakis; Jesper Bertram Bramsen; Torben Falck Ørntoft; Claus Lindbjerg Andersen; Ari Ristimäki; Anna Lepistö; Laura Renkonen-Sinisalo; Jukka-Pekka Mecklin; Jussi Taipale; Lauri A. Aaltonen
Source
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
In this study the authors examine the allelic imbalance (AI) landscape of colorectal cancer, reporting loss of TP53 as a driver of AI. They use CRISPR-Cas9 screens to identify 79 genes (within AI regions) regulating cell growth and identify a network of transcription factors that may contribute to colorectal tumorigenesis.