학술논문
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration
Document Type
article
Author
Xueping Liu; Dorte Helenius; Line Skotte; Robin N. Beaumont; Matthias Wielscher; Frank Geller; Julius Juodakis; Anubha Mahajan; Jonathan P. Bradfield; Frederick T. J. Lin; Suzanne Vogelezang; Mariona Bustamante; Tarunveer S. Ahluwalia; Niina Pitkänen; Carol A. Wang; Jonas Bacelis; Maria C. Borges; Ge Zhang; Bruce A. Bedell; Robert M. Rossi; Kristin Skogstrand; Shouneng Peng; Wesley K. Thompson; Vivek Appadurai; Debbie A. Lawlor; Ilkka Kalliala; Christine Power; Mark I. McCarthy; Heather A. Boyd; Mary L. Marazita; Hakon Hakonarson; M. Geoffrey Hayes; Denise M. Scholtens; Fernando Rivadeneira; Vincent W. V. Jaddoe; Rebecca K. Vinding; Hans Bisgaard; Bridget A. Knight; Katja Pahkala; Olli Raitakari; Øyvind Helgeland; Stefan Johansson; Pål R. Njølstad; João Fadista; Andrew J. Schork; Ron Nudel; Daniel E. Miller; Xiaoting Chen; Matthew T. Weirauch; Preben Bo Mortensen; Anders D. Børglum; Merete Nordentoft; Ole Mors; Ke Hao; Kelli K. Ryckman; David M. Hougaard; Leah C. Kottyan; Craig E. Pennell; Leo-Pekka Lyytikainen; Klaus Bønnelykke; Martine Vrijheid; Janine F. Felix; William L. Lowe; Struan F. A. Grant; Elina Hyppönen; Bo Jacobsson; Marjo-Riitta Jarvelin; Louis J. Muglia; Jeffrey C. Murray; Rachel M. Freathy; Thomas M. Werge; Mads Melbye; Alfonso Buil; Bjarke Feenstra
Source
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Gestational duration depends on both maternal and fetal genetic influences. Here, the authors perform a fetal genome-wide association meta-analysis and find that a locus on 2q13 is associated with pregnancy duration and further show that the lead SNP rs7594852 changes the binding properties of transcriptional repressor HIC1.