학술논문
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
Document Type
article
Author
Janina S. Ried; Janina Jeff M.; Audrey Y. Chu; Jennifer L. Bragg-Gresham; Jenny van Dongen; Jennifer E. Huffman; Tarunveer S. Ahluwalia; Gemma Cadby; Niina Eklund; Joel Eriksson; Tõnu Esko; Mary F. Feitosa; Anuj Goel; Mathias Gorski; Caroline Hayward; Nancy L. Heard-Costa; Anne U. Jackson; Eero Jokinen; Stavroula Kanoni; Kati Kristiansson; Zoltán Kutalik; Jari Lahti; Jian'an Luan; Reedik Mägi; Anubha Mahajan; Massimo Mangino; Carolina Medina-Gomez; Keri L. Monda; Ilja M. Nolte; Louis Pérusse; Inga Prokopenko; Lu Qi; Lynda M. Rose; Erika Salvi; Megan T. Smith; Harold Snieder; Alena Stančáková; Yun Ju Sung; Ioanna Tachmazidou; Alexander Teumer; Gudmar Thorleifsson; Pim van der Harst; Ryan W. Walker; Sophie R. Wang; Sarah H. Wild; Sara M. Willems; Andrew Wong; Weihua Zhang; Eva Albrecht; Alexessander Couto Alves; Stephan J. L. Bakker; Cristina Barlassina; Traci M. Bartz; John Beilby; Claire Bellis; Richard N. Bergman; Sven Bergmann; John Blangero; Matthias Blüher; Eric Boerwinkle; Lori L. Bonnycastle; Stefan R. Bornstein; Marcel Bruinenberg; Harry Campbell; Yii-Der Ida Chen; Charleston W. K. Chiang; Peter S. Chines; Francis S Collins; Fracensco Cucca; L Adrienne Cupples; Francesca D’Avila; Eco J .C. de Geus; George Dedoussis; Maria Dimitriou; Angela Döring; Johan G. Eriksson; Aliki-Eleni Farmaki; Martin Farrall; Teresa Ferreira; Krista Fischer; Nita G. Forouhi; Nele Friedrich; Anette Prior Gjesing; Nicola Glorioso; Mariaelisa Graff; Harald Grallert; Niels Grarup; Jürgen Gräßler; Jagvir Grewal; Anders Hamsten; Marie Neergaard Harder; Catharina A. Hartman; Maija Hassinen; Nicholas Hastie; Andrew Tym Hattersley; Aki S. Havulinna; Markku Heliövaara; Hans Hillege; Albert Hofman; Oddgeir Holmen; Georg Homuth; Jouke-Jan Hottenga; Jennie Hui; Lise Lotte Husemoen; Pirro G. Hysi; Aaron Isaacs; Till Ittermann; Shapour Jalilzadeh; Alan L. James; Torben Jørgensen; Pekka Jousilahti; Antti Jula; Johanne Marie Justesen; Anne E. Justice; Mika Kähönen; Maria Karaleftheri; Kay Tee Khaw; Sirkka M. Keinanen-Kiukaanniemi; Leena Kinnunen; Paul B. Knekt; Heikki A. Koistinen; Ivana Kolcic; Ishminder K. Kooner; Seppo Koskinen; Peter Kovacs; Theodosios Kyriakou; Tomi Laitinen; Claudia Langenberg; Alexandra M. Lewin; Peter Lichtner; Cecilia M. Lindgren; Jaana Lindström; Allan Linneberg; Roberto Lorbeer; Mattias Lorentzon; Robert Luben; Valeriya Lyssenko; Satu Männistö; Paolo Manunta; Irene Mateo Leach; Wendy L. McArdle; Barbara Mcknight; Karen L. Mohlke; Evelin Mihailov; Lili Milani; Rebecca Mills; May E. Montasser; Andrew P. Morris; Gabriele Müller; Arthur W. Musk; Narisu Narisu; Ken K. Ong; Ben A. Oostra; Clive Osmond; Aarno Palotie; James S. Pankow; Lavinia Paternoster; Brenda W. Penninx; Irene Pichler; Maria G. Pilia; Ozren Polašek; Peter P. Pramstaller; Olli T Raitakari; Tuomo Rankinen; D. C. Rao; Nigel W. Rayner; Rasmus Ribel-Madsen; Treva K. Rice; Marcus Richards; Paul M. Ridker; Fernando Rivadeneira; Kathy A. Ryan; Serena Sanna; Mark A. Sarzynski; Salome Scholtens; Robert A. Scott; Sylvain Sebert; Lorraine Southam; Thomas Hempel Sparsø; Valgerdur Steinthorsdottir; Kathleen Stirrups; Ronald P. Stolk; Konstantin Strauch; Heather M. Stringham; Morris A. Swertz; Amy J. Swift; Anke Tönjes; Emmanouil Tsafantakis; Peter J. van der Most; Jana V. Van Vliet-Ostaptchouk; Liesbeth Vandenput; Erkki Vartiainen; Cristina Venturini; Niek Verweij; Jorma S. Viikari; Veronique Vitart; Marie-Claude Vohl; Judith M. Vonk; Gérard Waeber; Elisabeth Widén; Gonneke Willemsen; Tom Wilsgaard; Thomas W. Winkler; Alan F. Wright; Laura M. Yerges-Armstrong; Jing Hua Zhao; M. Carola Zillikens; Dorret I. Boomsma; Claude Bouchard; John C. Chambers; Daniel I. Chasman; Daniele Cusi; Ron T. Gansevoort; Christian Gieger; Torben Hansen; Andrew A. Hicks; Frank Hu; Kristian Hveem; Marjo-Riitta Jarvelin; Eero Kajantie; Jaspal S. Kooner; Diana Kuh; Johanna Kuusisto; Markku Laakso; Timo A. Lakka; Terho Lehtimäki; Andres Metspalu; Inger Njølstad; Claes Ohlsson; Albertine J. Oldehinkel; Lyle J. Palmer; Oluf Pedersen; Markus Perola; Annette Peters; Bruce M. Psaty; Hannu Puolijoki; Rainer Rauramaa; Igor Rudan; Veikko Salomaa; Peter E. H. Schwarz; Alan R. Shudiner; Jan H. Smit; Thorkild I. A. Sørensen; Timothy D. Spector; Kari Stefansson; Michael Stumvoll; Angelo Tremblay; Jaakko Tuomilehto; André G. Uitterlinden; Matti Uusitupa; Uwe Völker; Peter Vollenweider; Nicholas J. Wareham; Hugh Watkins; James F. Wilson; Eleftheria Zeggini; Goncalo R. Abecasis; Michael Boehnke; Ingrid B. Borecki; Panos Deloukas; Cornelia M. van Duijn; Caroline Fox; Leif C. Groop; Iris M. Heid; David J. Hunter; Robert C. Kaplan; Mark I. McCarthy; Kari E. North; Jeffrey R. O'Connell; David Schlessinger; Unnur Thorsteinsdottir; David P. Strachan; Timothy Frayling; Joel N. Hirschhorn; Martina Müller-Nurasyid; Ruth J. F. Loos
Source
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
Past genome-wide associate studies have identified hundreds of genetic loci that influence body size and shape when examined one trait at a time. Here, Jeff and colleagues develop an aggregate score of various body traits, and use meta-analysis to find new loci linked to body shape.