학술논문
Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas
Document Type
article
Author
Jay Daniels; Peter G. Doukas; Maria E. Martinez Escala; Kimberly G. Ringbloom; David J. H. Shih; Jingyi Yang; Kyle Tegtmeyer; Joonhee Park; Jane J. Thomas; Mehmet E. Selli; Can Altunbulakli; Ragul Gowthaman; Samuel H. Mo; Balaji Jothishankar; David R. Pease; Barbara Pro; Farah R. Abdulla; Christopher Shea; Nidhi Sahni; Alejandro A. Gru; Brian G. Pierce; Abner Louissaint; Joan Guitart; Jaehyuk Choi
Source
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Cutaneous gamma-delta T cell lymphomas are rare but aggressive cancers. Here, by DNA, RNA and T cell receptor sequencing, the authors elucidate the molecular ontogeny by revising the cell of origin and identifying potentially targetable mutations.