학술논문
The Value of IgM Memory B-Cells in the Assessment of Splenic Function in Childhood Cancer Survivors at Risk for Splenic Dysfunction: A DCCSS-LATER Study
Document Type
article
Author
Bente M. Houtman; Iris Walraven; Elke de Grouw; Richard W. M. van der Maazen; Leontien C. M. Kremer; Eline van Dulmen-den Broeder; Marry M. van den Heuvel-Eibrink; Wim J. E. Tissing; Dorine Bresters; Helena J. H. van der Pal; Andrica C. H. de Vries; Marloes Louwerens; Margriet van der Heiden-van der Loo; Sebastian J. C. Neggers; Geert O. Janssens; Nicole M. A. Blijlevens; Annechien J. A. Lambeck; Frank Preijers; Jacqueline J. Loonen
Source
Journal of Immunology Research, Vol 2023 (2023)
Subject
Language
English
ISSN
2314-7156
Abstract
Background. Childhood cancer survivors (CCS) who received radiotherapy involving the spleen or total body irradiation (TBI) might be at risk for splenic dysfunction. A comprehensive screening test for examining splenic dysfunction is lacking. Objective. We investigated whether IgM memory B-cells could be used to assess splenic dysfunction in CCS who received a splenectomy, radiotherapy involving the spleen, or TBI. Methods. All CCS were enrolled from the DCCSS-LATER cohort. We analyzed differences in IgM memory B-cells and Howell–Jolly bodies (HJB) in CCS who had a splenectomy (n = 9), received radiotherapy involving the spleen (n = 36), or TBI (n = 15). IgM memory B-cells