학술논문
Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease
Document Type
article
Author
Source
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Huntington disease (HD) is a neurodegenerative disorder caused by the expansion of a polyglutamine tract in the huntingtin (mHtt) protein. Here the authors suggest that mHtt promotes ribosome stalling and inhibits protein synthesis.