학술논문
Association between Renal Function at Admission and COVID-19 in-Hospital Mortality in Southern Italy: Findings from the Prospective Multicenter Italian COVOCA Study
Document Type
article
Author
Raffaele Galiero; Vittorio Simeon; Giuseppe Loffredo; Alfredo Caturano; Luca Rinaldi; Erica Vetrano; Giulia Medicamento; Maria Alfano; Domenico Beccia; Chiara Brin; Sara Colantuoni; Jessica Di Salvo; Raffaella Epifani; Riccardo Nevola; Raffaele Marfella; Celestino Sardu; Carmine Coppola; Ferdinando Scarano; Paolo Maggi; Cecilia Calabrese; Pellegrino De Lucia Sposito; Carolina Rescigno; Costanza Sbreglia; Fiorentino Fraganza; Roberto Parrella; Annamaria Romano; Giosuele Calabria; Benedetto Polverino; Antonio Pagano; Fabio Giuliano Numis; Carolina Bologna; Mariagrazia Nunziata; Vincenzo Esposito; Nicola Coppola; Nicola Maturo; Rodolfo Nasti; Pierpaolo Di Micco; Alessandro Perrella; Miriam Lettieri; Luigi Elio Adinolfi; Paolo Chiodini; Ferdinando Carlo Sasso; on behalf of COVOCA Study Group
Source
Journal of Clinical Medicine, Vol 11, Iss 6121, p 6121 (2022)
Subject
Language
English
ISSN
2077-0383
Abstract
Background. Evidence has shown a close association between COVID-19 infection and renal complications in both individuals with previously normal renal function and those with chronic kidney disease (CKD). Methods. The aim of this study is to evaluate the in-hospital mortality of SARS-CoV-2 patients according to their clinical history of CKD or estimated glomerular filtration rate (eGFR). This is a prospective multicenter observational cohort study which involved adult patients (≥18 years old) who tested positive with SARS-CoV-2 infection and completed their hospitalization in the period between November 2020 and June 2021. Results. 1246 patients were included in the study, with a mean age of 64 years (SD 14.6) and a median duration of hospitalization of 15 days (IQR 9–22 days). Cox’s multivariable regression model revealed that mortality risk was strongly associated with the stage of renal impairment and the Kaplan–Meier survival analysis showed a progressive and statistically significant difference (p < 0.0001) in mortality according to the stage of CKD. Conclusion. This study further validates the association between CKD stage at admission and mortality in patients hospitalized for COVID-19. The risk stratification based on eGFR allows clinicians to identify the subjects with the highest risk of intra-hospital mortality despite the duration of hospitalization.