학술논문
Assessing the Impact of SARS-CoV-2 Lineages and Mutations on Patient Survival
Document Type
article
Author
Carlos Loucera; Javier Perez-Florido; Carlos S. Casimiro-Soriguer; Francisco M. Ortuño; Rosario Carmona; Gerrit Bostelmann; L. Javier Martínez-González; Dolores Muñoyerro-Muñiz; Román Villegas; Jesus Rodriguez-Baño; Manuel Romero-Gomez; Nicola Lorusso; Javier Garcia-León; Jose M. Navarro-Marí; Pedro Camacho-Martinez; Laura Merino-Diaz; Adolfo de Salazar; Laura Viñuela; The Andalusian COVID-19 Sequencing Initiative; Jose A. Lepe; Federico Garcia; Joaquin Dopazo
Source
Viruses, Vol 14, Iss 9, p 1893 (2022)
Subject
Language
English
ISSN
1999-4915
Abstract
Objectives: More than two years into the COVID-19 pandemic, SARS-CoV-2 still remains a global public health problem. Successive waves of infection have produced new SARS-CoV-2 variants with new mutations for which the impact on COVID-19 severity and patient survival is uncertain. Methods: A total of 764 SARS-CoV-2 genomes, sequenced from COVID-19 patients, hospitalized from 19th February 2020 to 30 April 2021, along with their clinical data, were used for survival analysis. Results: A significant association of B.1.1.7, the alpha lineage, with patient mortality (log hazard ratio (LHR) = 0.51, C.I. = [0.14,0.88]) was found upon adjustment by all the covariates known to affect COVID-19 prognosis. Moreover, survival analysis of mutations in the SARS-CoV-2 genome revealed 27 of them were significantly associated with higher mortality of patients. Most of these mutations were located in the genes coding for the S, ORF8, and N proteins. Conclusions: This study illustrates how a combination of genomic and clinical data can provide solid evidence for the impact of viral lineage on patient survival.