학술논문
GZMKhigh CD8+ T effector memory cells are associated with CD15high neutrophil abundance in non-metastatic colorectal tumors and predict poor clinical outcome
Document Type
article
Author
Silvia Tiberti; Carlotta Catozzi; Ottavio Croci; Mattia Ballerini; Danilo Cagnina; Chiara Soriani; Caterina Scirgolea; Zheng Gong; Jiatai He; Angeli D. Macandog; Amir Nabinejad; Carina B. Nava Lauson; Arianna Quinte’; Giovanni Bertalot; Wanda L. Petz; Simona P. Ravenda; Valerio Licursi; Paola Paci; Marco Rasponi; Luca Rotta; Nicola Fazio; Guangwen Ren; Uberto Fumagalli-Romario; Martin H. Schaefer; Stefano Campaner; Enrico Lugli; Luigi Nezi; Teresa Manzo
Source
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
The tumor immune microenvironment is an important prognostic determinant in colorectal cancer (CRC). Here the authors show that tumor infiltrating neutrophils expressing high levels of CD15 interact with CD8+ T effector memory skewing them to produce GZMK, associated with tumor progression in CRC patients.