학술논문
Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients
Document Type
article
Author
Nicolas Gonzalo Núñez; Jimena Tosello Boari; Rodrigo Nalio Ramos; Wilfrid Richer; Nicolas Cagnard; Cyrill Dimitri Anderfuhren; Leticia Laura Niborski; Jeremy Bigot; Didier Meseure; Philippe De La Rochere; Maud Milder; Sophie Viel; Delphine Loirat; Louis Pérol; Anne Vincent-Salomon; Xavier Sastre-Garau; Becher Burkhard; Christine Sedlik; Olivier Lantz; Sebastian Amigorena; Eliane Piaggio
Source
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Tumor-draining lymph nodes are often the first site of metastasis in breast cancer patients. Here, the authors show that metastatic lymph nodes are characterized by the accumulation of suppressive regulatory T cells with a distinct phenotype compared to matched non-invaded lymph nodes and tumors.