학술논문
Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node
Document Type
article
Author
Source
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Tumor neoantigens can be drained to the lymph nodes, but the nature and the significance of the induced immune responses are still unclear. Here the authors use a mouse genetic tumor model to show that tumor-specific CD4 T cells can become anergic or suppressive in the draining lymph node to modulate tumor immunity.