학술논문
Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis
Document Type
article
Author
John A. Lees; Bart Ferwerda; Philip H. C. Kremer; Nicole E. Wheeler; Mercedes Valls Serón; Nicholas J. Croucher; Rebecca A. Gladstone; Hester J. Bootsma; Nynke Y. Rots; Alienke J. Wijmega-Monsuur; Elisabeth A. M. Sanders; Krzysztof Trzciński; Anne L. Wyllie; Aeilko H. Zwinderman; Leonard H. van den Berg; Wouter van Rheenen; Jan H. Veldink; Zitta B. Harboe; Lene F. Lundbo; Lisette C. P. G. M. de Groot; Natasja M. van Schoor; Nathalie van der Velde; Lars H. Ängquist; Thorkild I. A. Sørensen; Ellen A. Nohr; Alexander J. Mentzer; Tara C. Mills; Julian C. Knight; Mignon du Plessis; Susan Nzenze; Jeffrey N. Weiser; Julian Parkhill; Shabir Madhi; Thomas Benfield; Anne von Gottberg; Arie van der Ende; Matthijs C. Brouwer; Jeffrey C. Barrett; Stephen D. Bentley; Diederik van de Beek
Source
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Streptococcus pneumoniae is a causative agent of meningitis and bacteremia. In a combined pathogen and host GWAS, Lees et al. find that host genetic variation is associated with both susceptibility and severity of pneumococcal meningitis, and specific bacterial genetic variation associated with susceptibility.