학술논문
Prior drug allergies are associated with worse outcome in patients with idiosyncratic drug-induced liver injury: A machine learning approach for risk stratification
Document Type
article
Author
Hao Niu; Pablo Solis-Muñoz; Miren García-Cortés; Judith Sanabria-Cabrera; Mercedes Robles-Diaz; Rocío Romero-Flores; Elvira Bonilla-Toyos; Aida Ortega-Alonso; José M. Pinazo-Bandera; María R. Cabello; Fernando Bessone; Nelia Hernandez; M. Isabel Lucena; Raúl J. Andrade; Inmaculada Medina-Caliz; Ismael Alvarez-Alvarez
Source
Pharmacological Research, Vol 199, Iss , Pp 107030- (2024)
Subject
Language
English
ISSN
1096-1186
Abstract
The impact of prior drug allergies (PDA) on the clinical features and outcomes of patients who develop idiosyncratic drug-induced liver injury (DILI) is largely unknown. We aimed to assess the clinical presentation and outcomes of DILI patients based on the presence or absence of PDA and explore the association between culprit drugs responsible for DILI and allergy. We analysed a well-vetted cohort of DILI cases enrolled from the Spanish DILI Registry. Bootstrap-enhanced least absolute shrinkage operator procedure was used in variable selection, and a multivariable logistic model was fitted to predict poor outcomes in DILI. Of 912 cases with a first episode of DILI, 61 (6.7%) had documented PDA. Patients with PDA were older (p = 0.009), had higher aspartate aminotransferase (AST) levels (p = 0.047), lower platelet count (p = 0.011) and higher liver-related mortality than those without a history of drug allergies (11% vs. 1.6%, p