학술논문

Ocular Graft Versus Host Disease Following Allogeneic Stem Cell Transplantation: A Review of Current Knowledge and Recommendations
Document Type
article
Source
Journal of Ophthalmic & Vision Research, Vol 8, Iss 4, Pp 351-358 (2013)
Subject
Allogeneic Stem Cell Transplantation
Bone Marrow Transplantation
Ocular Graft Versus Host Disease
Dry Eye
Keratoconjunctivitis Sicca
Ophthalmology
RE1-994
Language
English
ISSN
2008-322X
Abstract
Graft versus host disease (GVHD) is a common complication of allogeneic stem cell transplantation (allo-SCT). Ocular GVHD develops in approximately 40-60% of patients following allo-SCT and its most common clinical manifestations include keratoconjunctivitis sicca and cicatricial conjunctivitis. Ocular GVHD may lead to severe ocular surface disease, which can significantly diminish quality of life and restrict daily activities. It is thus important to monitor the condition closely since with timely diagnosis, irreversible damage can be avoided. The current review will focus on updated information regarding ocular GVHD.