학술논문
GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma.
Document Type
article
Author
Karin E Smedby; Jia Nee Foo; Christine F Skibola; Hatef Darabi; Lucia Conde; Henrik Hjalgrim; Vikrant Kumar; Ellen T Chang; Nathaniel Rothman; James R Cerhan; Angela R Brooks-Wilson; Emil Rehnberg; Ishak D Irwan; Lars P Ryder; Peter N Brown; Paige M Bracci; Luz Agana; Jacques Riby; Wendy Cozen; Scott Davis; Patricia Hartge; Lindsay M Morton; Richard K Severson; Sophia S Wang; Susan L Slager; Zachary S Fredericksen; Anne J Novak; Neil E Kay; Thomas M Habermann; Bruce Armstrong; Anne Kricker; Sam Milliken; Mark P Purdue; Claire M Vajdic; Peter Boyle; Qing Lan; Shelia H Zahm; Yawei Zhang; Tongzhang Zheng; Stephen Leach; John J Spinelli; Martyn T Smith; Stephen J Chanock; Leonid Padyukov; Lars Alfredsson; Lars Klareskog; Bengt Glimelius; Mads Melbye; Edison T Liu; Hans-Olov Adami; Keith Humphreys; Jianjun Liu
Source
PLoS Genetics, Vol 7, Iss 4, p e1001378 (2011)
Subject
Language
English
ISSN
1553-7390
1553-7404
1553-7404
Abstract
Non-Hodgkin lymphoma (NHL) represents a diverse group of hematological malignancies, of which follicular lymphoma (FL) is a prevalent subtype. A previous genome-wide association study has established a marker, rs10484561 in the human leukocyte antigen (HLA) class II region on 6p21.32 associated with increased FL risk. Here, in a three-stage genome-wide association study, starting with a genome-wide scan of 379 FL cases and 791 controls followed by validation in 1,049 cases and 5,790 controls, we identified a second independent FL-associated locus on 6p21.32, rs2647012 (OR(combined) = 0.64, P(combined) = 2 × 10(-21)) located 962 bp away from rs10484561 (r(2)