학술논문
Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming
Document Type
article
Author
Source
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
Reactivation of the inactive X chromosome (Xi) has modelled epigenetic reprogramming in mouse. Here, by using cell fusion between human female fibroblasts and mouse embryonic stem cells, the authors show a complex hierarchy of epigenetic changes that are required to reactivate the genes on the human Xi chromosome.