학술논문
A framework for clinical cancer subtyping from nucleosome profiling of cell-free DNA
Document Type
article
Author
Anna-Lisa Doebley; Minjeong Ko; Hanna Liao; A. Eden Cruikshank; Katheryn Santos; Caroline Kikawa; Joseph B. Hiatt; Robert D. Patton; Navonil De Sarkar; Katharine A. Collier; Anna C. H. Hoge; Katharine Chen; Anat Zimmer; Zachary T. Weber; Mohamed Adil; Jonathan B. Reichel; Paz Polak; Viktor A. Adalsteinsson; Peter S. Nelson; David MacPherson; Heather A. Parsons; Daniel G. Stover; Gavin Ha
Source
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Nucleosome profiling from cell-free DNA (cfDNA) represents a potential approach for cancer detection and classification. Here, the authors develop Griffin, a computational framework for tumour subtype classification based on cfDNA nucleosome profiling that can work with ultra-low pass sequencing data.