학술논문
Accuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia
Document Type
article
Author
Alexandre Nuzzo; Kevin Guedj; Sonja Curac; Claude Hercend; Claude Bendavid; Nathalie Gault; Alexy Tran-Dinh; Maxime Ronot; Antonino Nicoletti; Yoram Bouhnik; Yves Castier; Olivier Corcos; Katell Peoc’h; The SURVI (Structure d’URgences Vasculaires Intestinales) Research Group (French Intestinal Stroke Center)
Source
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Early diagnosis of acute mesenteric ischemia (AMI) remains a clinical challenge, and no biomarker has been consistently validated. We aimed to assess the accuracy of three promising circulating biomarkers for diagnosing AMI—citrulline, intestinal fatty acid-binding protein (I-FABP), and d-lactate. A cross-sectional diagnostic study enrolled AMI patients admitted to the intestinal stroke center and controls with acute abdominal pain of another origin. We included 129 patients—50 AMI and 79 controls. Plasma citrulline concentrations were significantly lower in AMI patients compared to the controls [15.3 μmol/L (12.0–26.0) vs. 23.3 μmol/L (18.3–29.8), p = 0.001]. However, the area under the receiver operating curves (AUROC) for the diagnosis of AMI by Citrulline was low: 0.68 (95% confidence interval = 0.58–0.78). No statistical difference was found in plasma I-FABP and plasma d-lactate concentrations between the AMI and control groups, with an AUROC of 0.44, and 0.40, respectively. In this large cross-sectional study, citrulline, I-FABP, and d-lactate failed to differentiate patients with AMI from patients with acute abdominal pain of another origin. Further research should focus on the discovery of new biomarkers.