학술논문
De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals
Document Type
article
Author
Guillaume Tetreau; Michael R. Sawaya; Elke De Zitter; Elena A. Andreeva; Anne-Sophie Banneville; Natalie A. Schibrowsky; Nicolas Coquelle; Aaron S. Brewster; Marie Luise Grünbein; Gabriela Nass Kovacs; Mark S. Hunter; Marco Kloos; Raymond G. Sierra; Giorgio Schiro; Pei Qiao; Myriam Stricker; Dennis Bideshi; Iris D. Young; Ninon Zala; Sylvain Engilberge; Alexander Gorel; Luca Signor; Jean-Marie Teulon; Mario Hilpert; Lutz Foucar; Johan Bielecki; Richard Bean; Raphael de Wijn; Tokushi Sato; Henry Kirkwood; Romain Letrun; Alexander Batyuk; Irina Snigireva; Daphna Fenel; Robin Schubert; Ethan J. Canfield; Mario M. Alba; Frédéric Laporte; Laurence Després; Maria Bacia; Amandine Roux; Christian Chapelle; François Riobé; Olivier Maury; Wai Li Ling; Sébastien Boutet; Adrian Mancuso; Irina Gutsche; Eric Girard; Thomas R. M. Barends; Jean-Luc Pellequer; Hyun-Woo Park; Arthur D. Laganowsky; Jose Rodriguez; Manfred Burghammer; Robert L. Shoeman; R. Bruce Doak; Martin Weik; Nicholas K. Sauter; Brian Federici; Duilio Cascio; Ilme Schlichting; Jacques-Philippe Colletier
Source
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
An environmentally safe means of mosquito control is the application of Bacillus thuringiensis israelensis, which produces a cocktail of four naturally crystalline proteins exclusively toxic to mosquito. Here the authors report the atomic-resolution structures of Bti Cry11Aa and related Btj Cry11Ba solved de novo through Serial Femtosecond Crystallography on naturally-occurring nanocrystals.