학술논문
Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b
Document Type
article
Author
Kensuke Shibata; Chihiro Motozono; Masamichi Nagae; Takashi Shimizu; Eri Ishikawa; Daisuke Motooka; Daisuke Okuzaki; Yoshihiro Izumi; Masatomo Takahashi; Nao Fujimori; James B. Wing; Takahide Hayano; Yoshiyuki Asai; Takeshi Bamba; Yoshihiro Ogawa; Makoto Furutani-Seiki; Mutsunori Shirai; Sho Yamasaki
Source
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
MR1 functions as an antigen presenting protein on cells in addition to MAIT cells. Here the authors use an early T cell-specific Bcl11b-deficient mouse that develops autoimmunity through a population of nonconventional MR1-restricted T cells and characterise their function.